Our group is led by Prof. Raphael Gottardo, Director of the Center, Full Professor in the Faculty of Biology and Medicine at the University of Lausanne, and Adjunct Professor at EPFL. The group focuses on the development and application of statistical and computational methods, in particular probabilistic and Bayesian approaches, to address major biological questions.
The group concentrates on the generation and analysis of data from recent technologies, including single-cell and spatial transcriptomics and proteomics, as well as their integration with clinical data. We adopt an end-to-end approach, from data generation to biological interpretation, to develop methods that are closely aligned with biological questions and maximize their impact.
The group’s activities span several key areas, including immunology, cancer immunotherapy, vaccinology, immune responses to infectious diseases, and dermatology.
Direction de l'innovation et de la recherche clinique,
Director of the BDSC, Full professor
Direction de l'innovation et de la recherche clinique, Director of operations
Direction de l'innovation et de la recherche clinique, Executive assistant
Direction de l'innovation et de la recherche clinique, Project manager
Direction de l'innovation et de la recherche clinique, Principal data scientist
Direction de l'innovation et de la recherche clinique, Senior data scientist
Direction de l'innovation et de la recherche clinique, Senior data scientist
Direction de l'innovation et de la recherche clinique, Senior data scientist
Direction de l'innovation et de la recherche clinique, Senior data scientist
Direction de l'innovation et de la recherche clinique, Data scientist
Direction de l'innovation et de la recherche clinique, Data scientist
Direction de l'innovation et de la recherche clinique, Senior software engineer
Direction de l'innovation et de la recherche clinique, Research scientist
Direction de l'innovation et de la recherche clinique, Postdoctoral researcher
Direction de l'innovation et de la recherche clinique,
PhD student
Direction de l'innovation et de la recherche clinique, PhD student
Direction de l'innovation et de la recherche clinique, PhD student
Direction de l'innovation et de la recherche clinique, PhD student
Direction de l'innovation et de la recherche clinique, PhD student
Direction de l'innovation et de la recherche clinique, PhD student
Direction de l'innovation et de la recherche clinique, Visiting Scientist
As part of the European IMMUcan project (Integrated iMMUnoprofiling of large adaptive CANcer patient cohorts), we are working on identifying new predictive biomarkers of response to immune checkpoint inhibitors.
We are part of the MOSAIC consortium, which aims to build the largest reference dataset in spatial omics for oncology. This dataset will help uncover treatment resistance mechanisms and improve patient stratification, ultimately paving the way for the discovery and development of personalized therapies.
We take part in the European SOLVE project, which aims to develop advanced vaccine technologies for stronger and longer-lasting protection against COVID-19. Within this project, our team builds and maintains a system for managing and analyzing high-dimensional data generated during vaccine trials.
Cheng H, Su Y, Pan X, Xu Y, Xie E, Du J, Chen DG, Dai X, Gottardo R, Greenberg PD, Li G
Nature
Bilous M, Buszta D, Bac J, Kang S, Dong Y, Tissot S, Andre S, Alexandre Gaveta M, Voize C, Peters S, Homicsko K, Gottardo R
Nat Methods
Zheng Y, Caron DP, Kim JY, Jun SH, Tian Y, Mair F, Stuart KD, Sims PA, Gottardo R
Nat Commun
Dong Y, Saglietti C, Bayard Q, Espin Perez A, Carpentier S, Buszta D, Tissot S, Dubois R, Kamburov A, Kang S, Haignere C, Sarkis R, Andre S, Alexandre Gaveta M, Lopez Lastra S, Piazzon N, Santos R, von Loga K, Hoffmann C, Coukos G, Peters S, Soumelis V, Durand EY, de Leval L, Gottardo R, Homicsko K, Madissoon E
Nat Commun
Crowell HL, Dong Y, Billato I, Cai P, Emons M, Gunz S, Guo B, Li M, Mahmoud A, Manukyan A, Pagès H, Panwar P, Rao S, Sargeant CJ, Kern LS, Ramos M, Sun J, Totty M, Carey VJ, Chen Y, Collado-Torres L, Ghazanfar S, Hansen KD, Martinowich K, Maynard KR, Patrick E, Righelli D, Risso D, Tiberi S, Waldron L, Gottardo R, Robinson MD, Hicks SC, Weber LM
bioRxiv
MOSAIC Consortium
bioRxiv
Seremet T, Di Domizio J, Girardin A, Yatim A, Jenelten R, Messina F, Saidoune F, Schlapbach C, Bogiatzi S, Minisini F, Garzorz-Stark N, Leuenberger M, Wüthrich H, Vernez M, Hohl D, Eyerich S, Eyerich K, Guenova E, Paul C, Gottardo R, Conrad C, Gilliet M
Nat Commun
Foglierini M, Nortier P, Schelling R, Winiger RR, Jacquet P, O'Dell S, Demurtas D, Mpina M, Lweno O, Muller YD, Petrovas C, Daubenberger C, Perreau M, Doria-Rose NA, Gottardo R, Perez L
Nat Commun
Hutchison WJ, Keyes TJ, tidyomics Consortium, Crowell HL, Serizay J, Soneson C, Davis ES, Sato N, Moses L, Tarlinton B, Nahid AA, Kosmac M, Clayssen Q, Yuan V, Mu W, Park JE, Mamede I, Ryu MH, Axisa PP, Paiz P, Poon CL, Tang M, Gottardo R, Morgan M, Lee S, Lawrence M, Hicks SC, Nolan GP, Davis KL, Papenfuss AT, Love MI, Mangiola S
Nat Methods
Barras D, Ghisoni E, Chiffelle J, Orcurto A, Dagher J, Fahr N, Benedetti F, Crespo I, Grimm AJ, Morotti M, Zimmermann S, Duran R, Imbimbo M, de Olza MO, Navarro B, Homicsko K, Bobisse S, Labes D, Tsourti Z, Andriakopoulou C, Herrera F, Pétremand R, Dummer R, Berthod G, Kraemer AI, Huber F, Thevenet J, Bassani-Sternberg M, Schaefer N, Prior JO, Matter M, Aedo V, Dromain C, Corria-Osorio J, Tissot S, Kandalaft LE, Gottardo R, Pittet M, Sempoux C, Michielin O, Dafni U, Trueb L, Harari A, Laniti DD, Coukos G
Sci Immunol
Moncunill G, Carnes J, Chad Young W, Carpp L, De Rosa S, Campo JJ, Nhabomba A, Mpina M, Jairoce C, Finak G, Haas P, Muriel C, Van P, Sanz H, Dutta S, Mordmüller B, Agnandji ST, Díez-Padrisa N, Williams NA, Aponte JJ, Valim C, Neafsey DE, Daubenberger C, McElrath MJ, Dobaño C, Stuart K, Gottardo R
Elife
Mair F, Erickson JR, Frutoso M, Konecny AJ, Greene E, Voillet V, Maurice NJ, Rongvaux A, Dixon D, Barber B, Gottardo R, Prlic M
Nature
Su Y, Yuan D, Chen DG, Ng RH, Wang K, Choi J, Li S, Hong S, Zhang R, Xie J, Kornilov SA, Scherler K, Pavlovitch-Bedzyk AJ, Dong S, Lausted C, Lee I, Fallen S, Dai CL, Baloni P, Smith B, Duvvuri VR, Anderson KG, Li J, Yang F, Duncombe CJ, McCulloch DJ, Rostomily C, Troisch P, Zhou J, Mackay S, DeGottardi Q, May DH, Taniguchi R, Gittelman RM, Klinger M, Snyder TM, Roper R, Wojciechowska G, Murray K, Edmark R, Evans S, Jones L, Zhou Y, Rowen L, Liu R, Chour W, Algren HA, Berrington WR, Wallick JA, Cochran RA, Micikas ME, ISB-Swedish COVID-19 Biobanking Unit, Wrin T, Petropoulos CJ, Cole HR, Fischer TD, Wei W, Hoon DSB, Price ND, Subramanian N, Hill JA, Hadlock J, Magis AT, Ribas A, Lanier LL, Boyd SD, Bluestone JA, Chu H, Hood L, Gottardo R, Greenberg PD, Davis MM, Goldman JD, Heath JR
Cell
Zhao E, Stone MR, Ren X, Guenthoer J, Smythe KS, Pulliam T, Williams SR, Uytingco CR, Taylor SEB, Nghiem P, Bielas JH, Gottardo R
Nat Biotechnol
Srivastava S, Furlan SN, Jaeger-Ruckstuhl CA, Sarvothama M, Berger C, Smythe KS, Garrison SM, Specht JM, Lee SM, Amezquita RA, Voillet V, Muhunthan V, Yechan-Gunja S, Pillai SPS, Rader C, Houghton AM, Pierce RH, Gottardo R, Maloney DG, Riddell SR
Cancer Cell
